??? ??????? ?? ?????? ?? ????? ?????? ? ??? ???? ???? ??????? ?? ????????? ??? ???? ? ???? ???? ????? ???????????? ????? ????????? ??? ????? ???? ??? ?????Inform clients and caregivers that likely deadly additive outcomes may arise if OPANA ER is utilised with benzodiazepines or other CNS depressants, together with Alcoholic beverages, rather than